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Futsis infusion of 100 ml. buy in Tashkent
Buy Futsis infusion of 100 ml.
Futsis infusion of 100 ml.

Futsis infusion of 100 ml.

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Uzbekistan, Tashkent
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Description

INSTRUCTION FUTSIS

Pharmacological action:

Futsis - antifungal drug of a broad spectrum of activity. Flukonazol - active ingredient of drug - synthetic derivative groups of tiazolovy connections. Flukonazol, due to selective influence on P450 cytochrome of mushrooms, leads to loss of enzymatic activity of specific connections in a mushroom cell. Thereof biosynthesis of styrene connections in a mushroom cell is broken, in particular process of transformation of a lanosterol into ergosterol is oppressed. Ergosterol makes a basis of a cellular membrane, and disturbance of its biosynthesis leads to increase of permeability and perforation of a cellular membrane of a mushroom owing to what there is his death. Besides, changes in a cellular membrane lead to disturbance of reproduction of mushrooms due to replication disturbance. Drug is effective concerning the majority of strains of Cryptococcus neoformans, Microsporum spp. and Trichophytum spp., Coccidioides immitis, Blastomyces dermatitidis, Hystoplasma capsulatum.

Drug is highly effective at the intracranial infections caused by Coccidioides immitis, Cryptococcus neoformans.

Flukonazol possesses high antifungal activity concerning Candida spp., including at generalized forms of an infection which developed against an immunosuppression.

Flukonazol malotoksichen for a human body as possesses sharp selectivity concerning P450 cytochrome of mushrooms and in insignificant degree influences tsitokhroma of the person. Flukonazol in comparison with other antifungal means of tiazolovy groups to a lesser extent oppresses cytochromdependent processes in a liver. Flukonazol does not exert the expressed impact on amount of androgenic hormones in a blood plasma.

After oral administration drug is well absorbed in a gastrointestinal tract. Flukonazol possesses high bioavailability (more than 90%), meal does not influence extent of absorption of drug. The peak of concentration of active agent in a blood plasma after oral administration is reached within 30-90 minutes.

Plasma concentration of drug are directly proportional to the accepted dose of a flukonazol. Extent of communication with proteins of plasma low (about 10%). Equilibrium concentration of drug are noted for 4-5 days of use (at oral administration of drug of 1 times a day), after reception of a shock dose of drug (the shock dose of a flukonazol is equal to two daily allowance), equilibrium concentration are reached for the second day of treatment. Drug well gets into all fabrics and biological liquids of an organism, so high concentration of a flukonazol are noted in saliva, a phlegm, epidermis and a derma. Drug well gets through a blood-brain barrier, concentration of a flukonazol in cerebrospinal fluid make about 80% of plasma concentration.


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Futsis infusion of 100 ml.
Futsis infusion of 100 ml.
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