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Citron of Jotas No. 10 powder for preparation of solution for intake buy in Tashkent
Buy Citron of Jotas No. 10 powder for preparation of solution for intake
Citron of Jotas No. 10 powder for preparation of solution for intake

Citron of Jotas No. 10 powder for preparation of solution for intake

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Price from:
30000 UZS
Uzbekistan, Tashkent
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Active ingredients (MNN): Paracetamol, fenilefrin, feniramin, ascorbic acid.


Dosage form: Powder for preparation of solution for intake.




One bag contains:


Active ingredients: paracetamol – 325 mg, a fenilefrina a hydrochloride – 10 mg, a feniramina a maleate – 20 mg, ascorbic acid – 50 mg.


Excipients: sodium citrate, apple acid, dye yellow sunset (dye yellow No. 6), dye hinolinovy yellow (dye yellow No. 10), titan dioxide, sucrose, fragrance lemon 3201, calcium phosphate, lemon acid.


Description: The loose white granulated powder with yellow impregnations without lumps and foreign particles with a citrus smell.


Pharmakoterapevtichesky group: Means for elimination of symptoms of ORZ and "cold" (analgeziruyushchy not narcotic средство+альфа-адреномиметик+Н1-гистаминовых receptors a blocker + vitamin).


ATH code: N02BE51


Pharmacological properties


The combined medicine which effect is caused by effects of the components making it.
Paracetamol – has soothing and febrifugal effect, mainly through braking of synthesis of prostaglandins in the central nervous system and, to a lesser extent, through blocking of formation of painful impulses. Peripheral action can be also caused by braking of synthesis of prostaglandins, or oppression of synthesis or effect of other substances responsible for sensitivity of pain receptors to mechanical or chemical stimulation.
Ascorbic acid - participates in regulation of oxidation-reduction processes, carbohydrate exchange, coagulability of blood, regeneration of fabrics, in synthesis of steroid hormones; reduces vascular permeability, reduces the need for B1, B2, A, E vitamins, folic acid, pantothenic acid. Improves tolerance of paracetamol and extends its action (it is connected with lengthening of elimination half-life (T1/2). Increases organism resilience to adverse factors to the environment.
Feniramina a maleate – has antiallergenic effect. Competing with a histamine for H1 receptors of effector cages, prevents the action of a histamine (hypostasis of fabrics and increase in permeability of capillaries) which is carried out through them, but does not eliminate its effects if they already developed. Provides additional reduction of a congestion of a nose, reduction of cold and sneezing.
Fenilefrin a hydrochloride - stimulates postsynaptic alpha adrenoceptors. Causes narrowing arteriol, increase HELL (with possible reflex bradycardia), increase in OPSS. Exerts the insignificant stimulating impact on a head and spinal cord. Reduces a blood-groove — kidney, skin, in abdominal organs and extremities. Narrows pulmonary vessels and increases pressure in a pulmonary artery. As the vazokonstriktor has antikongestivny effect: reduces hypostasis and hyperaemia of a mucous membrane of a nose, expressiveness of ekssudativny manifestations, restores free breath; lowers pressure in paranasal cavities and on average an ear.




Paracetamol – is quickly and evenly distributed generally in soft fabrics, T1/2 is equal from 1,25 to 3 hours. It is metabolized in a liver with participation of mikrosomalny fermental systems. About 85% of the dose of paracetamol accepted oralno are removed with urine (in the form of the free and conjugated paracetamol) within 24 hours.
Ascorbic acid - is well soaked up from a GIT (in a small intestine) and distributed in fabrics, especially nadpochechnikovy glands. It is metabolized mainly in a liver, turning dezoksiaskorbinovy and further into shchavelevouksusny and diketogulonovy acids. Not changed ascorbate and metabolites are removed with urine, then, breast milk.
Feniramina a maleate – after application inside slowly, but is completely soaked up in digestive tract. Linkng with proteins of plasma of blood – high (72%). Biotransformation in a liver, and also in kidneys. T1/2 – 14-25 hours, is brought out of an organism through kidneys, in the form of metabolites.


Indications to application


The SARS (symptomatic therapy), allergic rhinitis, rinofaringit.


Method of application and doses


Inside, to adults and children 12 years on 1 bag 2-3 times a day are more senior. Contents of a bag are dissolved in enough hot water. The interval between receptions of medicine has to make not less than 4 h. At a renal failure the interval between receptions of medicine has to make not less than 8 h. Reception duration without consultation of the doctor no more than 3 days as febrifuge.


Side effects


Allergic reactions (skin rash, itch, small tortoiseshell, angioneurotic hypostasis), nausea, epigastralny pain; anemia, thrombocytopenia; dryness in a mouth, accommodation paresis, an urine delay, drowsiness. At prolonged use in high doses – hepatotoxic action, hemolytic anemia, aplastic anemia, a metgemoglobinemiya, pan-cytosinging; erosive and ulcer damages of a GIT, bleeding in a GIT; nefrotoksichnost (papillary necrosis).




Hypersensibility to paracetamol, ascorbic acid, a feniramina to a maleate or any other component of medicine. Erosive and ulcer damages of digestive tract (in an aggravation phase), a renal failure, portal hypertensia, chronic alcoholism, deficiency degidrogenaza glyukozo-6-phosphate, children's age up to 12 years, the period of pregnancy and a lactation.


Medicinal interactions


Ethanol strengthens sedative action of a feniramin of a maleate.
Antidepressants, protivoparkinsonichesky, antipsychotic (derivatives of a fenotiazin) medicines increase risk of development of side effects of medicine (an urine delay, dryness in a mouth, locks).
Joint reception of glucocorticosteroids increases risk of development of glaucoma.
Inductors of mikrosomalny oxidation (fenitoin, ethanol, barbiturates, rifampicin, phenylbutazone, tritsiklichesky antidepressants) increase production of gidroksilirovanny active metabolites, increasing risk of development of heavy intoxications at small overdoses of medicine.
Inhibitors of mikrosomalny oxidation (tsimetidin) reduce risk of hepatotoxic effect of paracetamol.
Paracetamol reduces efficiency of urikozurichesky medicines.


Special instructions


At the hyperthermia proceeding against the background of treatment by medicine more than 3 days consultation of the doctor is required.
Reception of medicine distorts indicators of laboratory researches at quantitative definition of glucose and uric acid in plasma.
During treatment control of a picture of peripheral blood and a functional condition of a liver is necessary.
During treatment it is necessary to abstain from the ethanol use (possibly development of hepatotoxic action), driving of motor transport and occupations other potentially dangerous kinds of activity demanding the increased concentration of attention and speed of psychomotor reactions.
Take at congenital giperbilirubinemiya with caution (Gilbert's syndromes, the Cudgel Johnson and the Rotor), closed-angle glaucoma, a prostate gland giperplaziya, viral hepatitis, alcoholic hepatitis, at elderly people.
Pregnancy and period of a lactation
It is not recommended to apply medicine at pregnancy and in the period of a lactation due to the lack of data on safe use of medicine for these persons.
Medicine should be stored in the place, inaccessible for children, and not to use after expiry date.








Toxic action at adults perhaps after reception as a part of medicine over 10-15 g of paracetamol.
Symptoms (are caused by paracetamol): pallor of integuments, loss of appetite, nausea, vomiting; gepatonekroz (expressiveness of a necrosis owing to intoxication directly depends on extent of overdose), increase in activity "hepatic" transaminaz, increase in protrombinovy time (in 12-48 h after reception); the developed clinical picture of damage of a liver is shown in 1-6 days. Seldom: the liver failure develops immediately and can be complicated by a renal failure (a tubulyarny necrosis).
Treatment: in the first 6 h after overdose – washing of a stomach, introduction of donators of SH-group and predecessors of synthesis of glutathione – methionine in 8-9 h after overdose and N-atsetiltsisteina in 12 h. Need for holding additional therapeutic actions (further introduction of methionine, in/in introduction of N-atsetiltsisteina) is defined by concentration of paracetamol in blood, and also time which passed after its reception.


Release form


Powder for preparation of solution for intake on 22.1 g in bags.


Storage conditions


In the dry place protected from light, at a temperature not above 25ºС.


Expiration date


2 years.


Holiday conditions from drugstores


Without recipe.

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Citron of Jotas No. 10 powder for preparation of solution for intake
Citron of Jotas No. 10 powder for preparation of solution for intake
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