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Lidocaine 137-58-6 buy in Shijiazhuang
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Lidocaine 137-58-6

Lidocaine 137-58-6

Code: GL-006
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Technical characteristics
  • BrandCrovell
  • Country of manufactureChina
  • PackagingBag
  • Purity99.9%
Description
Lidocaine Basic information
description Chemical property Uses
Product Name: Lidocaine
Synonyms: 2-(Diethylamino)-2',6'-acetoxylidide;2-(diethylamino)-2’,6’-acetoxylidide;2-(diethylamino)-n-(2,6-dimethylphenyl)-acetamid;2',6'-Acetoxylidide, 2-(diethylamino)-;6’-acetoxylidide,2-(diethylamino)-2;Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-;Acetamide,2-(diethylamino)-N-(2,6-dimethylphenyl)-;a-Diethylamino-2,6-acetoxylidide
CAS: 137-58-6
MF: C14H22N2O
MW: 234.34
EINECS: 205-302-8
Product Categories: Research Chemical;Alphacaine, Xylocaine, lignocaine;REGITINE;Other APIs;Pharma materials;API;Halogenated Heterocycles
Mol File: 137-58-6.mol
Lidocaine Structure
 
Lidocaine Chemical Properties
Melting point  66-69°C
Boiling point  bp4 180-182°; bp2 159-160°
density  0.9944 (rough estimate)
refractive index  1.5110 (estimate)
Fp  9℃
storage temp.  Store at RT
solubility  ethanol: 4 mg/mL
form  powder
pka pKa 7.88(H2O)(Approximate)
color  White to slightly yellow
Water Solubility  practically insoluble
Merck  14,5482
Stability: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 137-58-6(CAS DataBase Reference)
NIST Chemistry Reference Lidocaine(137-58-6)
EPA Substance Registry System Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)- (137-58-6)
 
Safety Information
Hazard Codes  Xn,T,F
Risk Statements  22-39/23/24/25-23/24/25-11
Safety Statements  22-26-36-45-36/37-16-7
RIDADR  3249
WGK Germany  3
RTECS  AN7525000
HazardClass  6.1(b)
PackingGroup  III
Hazardous Substances Data 137-58-6(Hazardous Substances Data)
MSDS Information
Provider Language
Xylocaine English
 
Lidocaine Usage And Synthesis
description Lidocaine is a local anesthetic, also known as Xylocaine, in recent years it has been replaced procaine, widely used in local infiltration anesthesia in cosmetic plastic surgery, it can block the nerve excitability and conduction by inhibiting the sodium channels of nerve cell membrane. The fat soluble and protein binding rate of lidocaine is higher than procaine, its cell penetrating ability is strong, fast onset, long duration of action, the interaction strength is 4 times of procaine.
Lidocaine is used in infiltration anesthesia, epidural anesthesia, topical anesthesia (including thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve block. In order to extend the time of anesthesia, reduce the poisoning of lidocaine and other side effects, can be added in the anesthetic epinephrine.
Lidocaine can also be used for the treatment of ventricular premature beat after acute myocardial infarction, ventricular tachycardia, digitalis poisoning, cardiac surgery and cardiac catheterization-induced ventricular arrhythmias, including ventricular premature beats, ventricular tachycardia and ventricular fibrillation. Lidocaine is also used for duration status of epilepsy which other anti-seizure drugs are not effective, as well as local or spinal anesthesia. But it is usually ineffective for supraventricular arrhythmias.
Chemical property Lidocaine is white needle like crystals, and its melting point is 68-69℃; boiling point is 180-182℃ (0.53kPa), soluble in ethanol in 159-160℃ (0.267kPa), ether, benzene, chloroform and oil, do not dissolve in water. In common use radical hydrochloride, lidocaine hydrochloride (C14H22N2O • HCL, [73-78-9]) is a white crystalline powder. Melting point 127-129℃, and the monohydrate melting point is 77-78℃. Easily soluble in water, 0.5% aqueous solution pHO 4.0-5.5. Odorless, bitter taste.
Uses 1, This product is a local anesthetics of amide derivatives,and widely used in surface anesthesia, anesthesia, conduction anesthesia and epidural anesthesia. The LD50 of oral lidocaine hydrochloride to mice was 290 mg/kg.
2, Used as a local anesthetic.
Chemical Properties solid
Uses Lidocaine (Alphacaine)is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. [1] Histamine is responsible for many features of allergic reactions. Lidocaine (Alphacaine)is a second-generation antihistamine agent closely st
Uses antihypertensive
Uses Anticonvulsant
Uses Antiarrhythmic Agents, Anesthetics
Definition ChEBI: The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Brand name Alphacaine (Carlisle); Lidoderm (Teikoku); Xylocaine (AstraZeneca).
Biological Activity Anasthetic and class Ib antiarrhythmic agent.? Blocks voltage-gated sodium channels in the inactivated state.
Contact allergens Lidocaine is an anesthetic of the amide group, like articaine or bupivacaine. Immediate-type IgE-dependent reactions are rare, and delayed-type contact dermatitis is exceptional. Cross-reactivity between the different amide anesthetics is not systematic.

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